IMMUNOBIOLOGY Requirement of the human T-cell leukemia virus p12 and p30 products for infectivity of human dendritic cells and macaques but not rabbits
نویسندگان
چکیده
1Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD; 2Basic Research Program, SAIC-Frederick Inc, National Cancer Institute–Frederick, Frederick, MD; 3Advanced BioScience Laboratories Inc, Kensington, MD; 4 Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS; and 5Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute–Frederick, Frederick, MD
منابع مشابه
Requirement of the human T-cell leukemia virus p12 and p30 products for infectivity of human dendritic cells and macaques but not rabbits.
The identification of the genes necessary for human T-cell leukemia virus (HTLV-1) persistence in humans may provide targets for therapeutic approaches. We demonstrate that ablation of the HTLV-1 genes encoding p12, p30, or the HBZ protein, does not affect viral infectivity in rabbits and in this species, only the absence of HBZ is associated with a consistent reduction in virus levels. We obse...
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تاریخ انتشار 2010